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Updated: Jan 20, 2026
Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions
Published on: July 3, 2025
Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
Xing He1, Ziyan Zhou1, Zhuo Han2
1School of Material Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Abstract:
The physical and chemical interactions with vancomycin (VAN) were accessed between graphene oxide (GO) and crumpled graphene oxide (CGO) to present the possible loading and release mechanisms. The improved hydrophilicity and surface charge were found on CGO through water contact angle and ζ-potential measurements. Fourier transform infrared and X-ray photoelectron spectroscopies confirmed the attachment of VAN onto CGO or GO through π-π stacking and hydrogen bonding. Both CGO-VAN and GO-VAN drug complexes showed pH-controlled release property. The high VAN loading and delayed release in CGO-VAN system were mainly due to the crumpled morphology.
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