[Ceftriaxone-resistant Streptococcus pneumoniae meningitis: case report].

Area of Science:

• Neurology
• Infectious Diseases
• Microbiology

Background:

• Infectious meningitis is a critical medical condition.
• Streptococcus pneumoniae is the primary cause of bacterial meningitis.
• Empirical antibiotic treatment, often with third-generation cephalosporins like ceftriaxone, is crucial.

Observation:

• Ceftriaxone resistance in Streptococcus pneumoniae is an increasing global concern.
• A 56-year-old male presented with acute infectious meningitis.
• The patient was diagnosed with hypothyroidism and mega cisterna magna during hospitalization.

Findings:

• The meningitis was caused by ceftriaxone-resistant Streptococcus pneumoniae.
• Combined empirical treatment with ceftriaxone and vancomycin proved effective.
• The patient showed a favorable response to the combined antibiotic regimen.

Implications:

• Current empirical antibiotic strategies for bacterial meningitis may need revision.
• Vancomycin in combination with ceftriaxone offers a viable treatment option for ceftriaxone-resistant pneumococcal meningitis.
• This case highlights the importance of monitoring antibiotic resistance patterns and adapting treatment protocols.