Related Experiment Video
Updated: Jan 20, 2026
Intrabronchial Instillation of Streptococcus pneumoniae in Immunocompetent Rodent Models
[Ceftriaxone-resistant Streptococcus pneumoniae meningitis: case report]
Marcos Saavedra-Velasco1,2, Mariel Tapia-Cruz1, J Antonio Grandez-Urbina2,3
1Servicio de Infectología, Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú.
Abstract:
Infectious meningitis is a medical emergency. Within the spectrum of infectious agents, the most important is Streptococcus pneumoniae, the most frequent etiological agent of bacterial meningitis. The initiation of empirical antimicrobial treatment bears great importance and considers third-generation cephalosporins as the first alternative. However, cases of ceftriaxone resistance have been reported in several regions of the world. This has become an emerging problem in need of reconsideration of the current empirical antibiotic treatment schemes. We present the case of a 56-year old man with acute infectious meningitis caused by ceftriaxone-resistant Streptococcus pneumoniae, who responded favorably to combined empirical treatment with ceftriaxone and vancomycin and to whom, during his hospital stay, the presence of hypothyroidism and mega cisterna magna was diagnosed.
Insights
Bacterial meningitis caused by ceftriaxone-resistant Streptococcus pneumoniae requires updated treatment. A case study shows combined ceftriaxone and vancomycin therapy is effective for this emerging infectious disease.
Area of Science:
- Neurology
- Infectious Diseases
- Microbiology
Background:
- Infectious meningitis is a critical medical condition.
- Streptococcus pneumoniae is the primary cause of bacterial meningitis.
- Empirical antibiotic treatment, often with third-generation cephalosporins like ceftriaxone, is crucial.
Observation:
- Ceftriaxone resistance in Streptococcus pneumoniae is an increasing global concern.
- A 56-year-old male presented with acute infectious meningitis.
- The patient was diagnosed with hypothyroidism and mega cisterna magna during hospitalization.
Findings:
- The meningitis was caused by ceftriaxone-resistant Streptococcus pneumoniae.
- Combined empirical treatment with ceftriaxone and vancomycin proved effective.
- The patient showed a favorable response to the combined antibiotic regimen.
Implications:
- Current empirical antibiotic strategies for bacterial meningitis may need revision.
- Vancomycin in combination with ceftriaxone offers a viable treatment option for ceftriaxone-resistant pneumococcal meningitis.
- This case highlights the importance of monitoring antibiotic resistance patterns and adapting treatment protocols.
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