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Updated: Jan 20, 2026

Gold Nanoparticle Synthesis
Published on: July 10, 2021
Gold-Catalyzed Synthesis of 6-Hydroxyindoles from Alkynylcyclohexadienones and Substituted Amines
Veerabhushanam Kadiyala1, Perla Bharath Kumar1, Sridhar Balasubramanian2
1Fluoro and Agrochemicals Department , Academy of Scientific and Innovative Research , Ghaziabad 201002 , India.
Abstract:
An efficient gold-catalyzed formation of 6-hydroxyindoles from substituted alkynylcyclohexadienones and amines have been developed. In this reaction two new C-N bonds were formed, and moderate to very good yields of the 6-hydroxyindole derivatives were obtained in one pot. This organic transformation tolerates a range of substituted alkynylcyclohexadienones and amines, which resulted in 6-hydroxyindole derivatives selectively.
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Nucleophilic Substitution
Nucleophilic substitution reactions are among the most fundamental topics covered in organic chemistry. A nucleophilic substitution reaction is one where a nucleophile (electron-rich Lewis base) replaces a leaving group from a carbon atom.
SN1 (S = Substitution, N = Nucleophilic, 1 = first-order kinetics)
SN2 (S = Substitution, N = Nucleophilic, 2 = second-order kinetics)
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