Related Experiment Video

Updated: Jan 20, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

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Impact of adenotonsillectomy on the evolution of inflammatory markers

Martín E Marcano-Acuña1, Marina Carrasco-Llatas1, Miguel Tortajada-Girbés2,3

  • 1Department of Ear Nose & Throat (ENT), Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Dr. Peset University Hospital, Valencia, Spain.

Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
|August 29, 2019
PubMed

Insights

Adenotonsillectomy in children with chronic tonsillitis or hypertrophy significantly reduces inflammatory markers like hs-CRP and TNF-α. One year post-surgery, these inflammatory markers return to normal levels, indicating the procedure

Area of Science:

  • Immunology
  • Pediatric Otolaryngology

Background:

  • Tonsils are crucial for host defense and immunity.
  • Persistent inflammation linked to tonsil issues can increase morbidity.
  • Elevated inflammatory markers are observed in children requiring adenotonsillectomy.

Purpose of the Study:

  • To assess the short- and long-term effects of adenotonsillectomy on inflammatory markers in children aged 3-9.
  • To evaluate changes in cytokines and other inflammatory indicators post-tonsillectomy.

Main Methods:

  • Prospective, longitudinal study of 29 children undergoing adenotonsillectomy.
  • Measured high-sensitivity C-reactive protein (hs-CRP), Th1/Th2 cytokines, TGF-β, and ICAM-1.
  • Compared results with 29 control children over one year.

Main Results:

  • Baseline elevated hs-CRP, IL-1, IL-10, IFN-γ, TNF-α, and ICAM-1 in surgical candidates.
  • Children with severe obstruction showed different cytokine profiles (IL-1, IL-4, IL-5, IL-10).
  • One year post-surgery, inflammatory markers normalized compared to controls; hs-CRP and TNF-α decreased within one month.

Conclusions:

  • Children with chronic tonsillitis/hypertrophy exhibit elevated proinflammatory cytokines.
  • Adenotonsillectomy effectively normalizes these inflammatory parameters within one year.
Abstract

Keywords:
Otorhinolaryngologyadenoidsimmunologyobstructive sleep apnoearhinologysleep disordered breathingtonsils ORL

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