Related Concept Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

The outcome of patients with acute ischemic stroke depends on swift restoration of cerebral blood flow. This protocol aims at optimizing the management of such patients by minimizing peri-procedural timings and rendering the time from hospital admission to reperfusion as short as...
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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Rat in vivo models are indispensable tools to investigate the pathological mechanisms and therapeutic targets for ischemic stroke. This work will describe performing immunofluorescence staining in infarcted brain slices following middle cerebral artery occlusion (MCAO) in...
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Assessing the Angiogenesis Effects of a Test Drug in a Rat Model of Ischemic Stroke01:18

Assessing the Angiogenesis Effects of a Test Drug in a Rat Model of Ischemic Stroke

Begin with a rat subjected to middle cerebral artery occlusion, a surgical procedure that temporarily blocks blood flow to the brain tissue.This induces an ischemic stroke, leading to brain tissue damage.Next, remove the blockage to restore blood flow.Select rats that exhibit neurological deficits to ensure study relevance.Then, administer the test drug to the experimental group while injecting saline into the other group.Repeat the drug and saline administration.The test drug promotes...
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Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Continuous arterial blood pressure recording allows the investigation of impacts of various hemodynamic parameters. This report demonstrates the application of continuous arterial blood pressure monitoring in a large animal model of ischemic stroke for determination of stroke pathophysiology, impact of different hemodynamic factors, and the assessment of novel treatment...
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Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique07:34

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Here, we present a protocol to establish a distal middle cerebral artery occlusion (dMCAO) model through transcranial electrocoagulation in C57BL/6J mice and evaluate the subsequent neurological behavior and histopathological...
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Inducing Ischemic Stroke via Middle Cerebral Artery Occlusion Using a Thread Bolt03:22

Inducing Ischemic Stroke via Middle Cerebral Artery Occlusion Using a Thread Bolt

This video demonstrates the process of inducing ischemic stroke in a rat model by occluding the middle cerebral artery (MCA) using a thread bolt. The procedure involves ligating the carotid arteries, inserting a thread bolt into the external carotid artery, and blocking blood flow from the MCA to the brain, leading to neuronal death and mimicking an ischemic...
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