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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

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Basophil activation test is a potent tool for the detection of IgE-dependent allergies in vitro. Here, an optimized protocol for basophil activation test is used to investigate drug hypersensitivity. A method for the efficient production of covalent drug-protein conjugates and their physicochemical characterization is...
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Antibiotic Selection00:57

Antibiotic Selection

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Overview
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Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid05:43

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This protocol describes the development of a mouse model with cough hypersensitivity, which can serve as an ideal model for studying the mechanisms of chronic...
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Contact hypersensitivity (CHS) is a murine experimental model of allergic contact dermatitis (ACD). CHS is based on sensitization with reactive hapten by painting the shaved skin of the chest and abdomen, with a subsequent ear skin challenge with a diluted hapten, causing a swelling reaction that is assessed in various...
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Due to the simplicity of surgery and the robust behavioural outcome, chronic constriction of the sciatic nerve is one of the pre-eminent animal models of neuropathic pain. Within 24 hrs following surgery, pain hypersensitivity is established and can be quantitatively measured using a von Frey aesthesiometer (mechanical test) and plantar analgesia meter (thermal...
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Related Experiment Video

Updated: Jan 20, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

34.1K

Antibiotic Hypersensitivity Mechanisms.

Jenana H Maker1, Cassandra M Stroup2, Vanthida Huang3

  • 1Department of Pharmacy Practice, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA. jmaker@pacific.edu.

Pharmacy (Basel, Switzerland)
|August 30, 2019
PubMed
Summary
This summary is machine-generated.

Antibiotic hypersensitivity reactions can manifest in four immune-mediated types, including IgE-mediated, antibody-mediated, immune complex, and T-cell mediated responses. Accurate recognition and management are crucial for patient safety.

Keywords:
Type IType IIType IIIType IVallergyanaphylaxisantibioticantimicrobialhypersensitivity

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Related Experiment Videos

Last Updated: Jan 20, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

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Area of Science:

  • Immunology
  • Pharmacology
  • Clinical Medicine

Background:

  • Antibiotics are frequently prescribed for bacterial infections.
  • Hypersensitivity reactions to antibiotics are a significant clinical concern.
  • Accurate identification and management of these reactions are essential.

Purpose of the Study:

  • To elucidate the mechanisms of different types of allergic reactions to common antibiotics.
  • To provide recommendations for the appropriate management of antibiotic hypersensitivity.
  • To differentiate immune-mediated reactions from non-immune mediated pseudoallergies.

Main Methods:

  • Review of literature on antibiotic hypersensitivity mechanisms.
  • Classification of reactions into Type I, II, III, and IV hypersensitivity.
  • Discussion of clinical presentations and diagnostic considerations.
  • Outline of management strategies for each reaction type.

Main Results:

  • Type I reactions: IgE-mediated, potential for anaphylaxis.
  • Type II reactions: Antibody-mediated, leading to cytopenias (thrombocytopenia, neutropenia, hemolytic anemia).
  • Type III reactions: Immune complex formation, associated with vasculitis.
  • Type IV reactions: T-cell mediated, presenting as rashes with or without systemic symptoms.

Conclusions:

  • Understanding the distinct mechanisms of antibiotic hypersensitivity is key for accurate diagnosis.
  • Tailored management strategies are necessary for each reaction type.
  • Distinguishing true hypersensitivity from pseudoallergic reactions is important for appropriate patient care.