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Related Experiment Video

Updated: Jan 20, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Plaque Calcification: Do Lipoproteins Have a Role?

Emma J Akers1,2, Stephen J Nicholls3, Belinda A Di Bartolo4

  • 1From the South Australian Health and Medical Research Institute, Adelaide, Australia (E.J.A.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|August 30, 2019
PubMed
Summary

High-density lipoproteins may inhibit vascular calcification (VC), while LDL and VLDL may stimulate it. Understanding lipoprotein roles in VC could lead to new treatments for this cardiovascular risk factor.

Keywords:
atherosclerosiskidneylipoproteinsphenotypeplaquetriglyceridesvascular calcification

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Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Vascular Biology

Background:

  • Vascular calcification (VC) is a significant predictor of cardiovascular events and mortality.
  • Current treatments for VC are lacking due to its complex nature.
  • Lipoproteins are key in atherosclerosis, but their role in VC is not fully understood.

Purpose of the Study:

  • To review the current understanding of lipoprotein involvement in vascular calcification.
  • To explore potential therapeutic targets for VC based on lipoprotein interactions.

Main Methods:

  • Review of early in vitro data.
  • Analysis of clinical correlations.
  • Examination of lipoprotein roles in plaque calcification.

Main Results:

  • High-density lipoproteins (HDL) may inhibit VC.
  • Low-density lipoproteins (LDL) and very-low-density lipoproteins (VLDL) may stimulate VC.
  • Lipoprotein (a) [Lp(a)] may have a causal role in VC.
  • Statin or PCSK9 inhibitor treatment may increase plaque calcification.

Conclusions:

  • Lipoprotein-artery wall interactions are critical in VC pathogenesis.
  • Targeted therapies for VC may emerge from understanding these mechanisms.
  • Further research into lipoprotein roles could refine VC treatment strategies.