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Updated: Jan 20, 2026
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report
Shuwen Zhong1, Jingqing Zeng1, Zhaohui Deng2
1Department of Pediatric Gastroenterology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong Area, Shanghai, 200127, China.
Background:
Immunocompromised (IC) patients have an increased risk of refractory diarrhea. Fecal microbiota transplantation (FMT) is a safe and effective therapy for infection-related diarrhea which are mainly mediated by the loss of the microbial colonization, although there is concern that IC patients may be at higher risk of infectious complications related to FMT. And reports of FMT in IC children are limited.
Case Presentation:
We describe two cases of FMT in IC children with refractory diarrhea. One IC child had polyendocrinopathy, enteropathy, X-linked syndrome and the other child had graft-versus-host disease. Both of the children had a long course of diarrhea and no response to traditional treatment. FMT was performed on both patients via nasojejunal tubes under guidance of gastroduodenoscopy. After FMT, the patients achieved remission of symptoms and neither of them had related infectious complications. Microbiota analysis showed that FMT resulted in reconstruction of a diverse microbiota.
Conclusions:
Use of FMT is safe and effective in treatment of refractory diarrhea in IC children with a damaged microbiota.
Insights
Fecal microbiota transplantation (FMT) effectively treated refractory diarrhea in immunocompromised children. This safe procedure restored diverse gut microbiota without infectious complications, offering a new therapeutic option for this vulnerable population.
Area of Science:
- Pediatric Gastroenterology
- Microbiome Research
- Immunocompromised Patient Care
Background:
- Immunocompromised (IC) children face increased risks of refractory diarrhea.
- Fecal microbiota transplantation (FMT) is effective for diarrhea but safety in IC patients is debated.
- Limited data exists on FMT use in pediatric IC populations.
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