Related Experiment Video

Updated: Jan 20, 2026

Aneurysm II: Clinical Manifestations and Diagnostic Studies
01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Published on: June 19, 2025

312

Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children

Esther Burden-Teh1, Ruth Murphy2, Sonia Gran2

  • 1Centre of Evidence Based Dermatology, School of Medicine, University of Nottingham, Nottingham, UK esther.burden-teh@nottingham.ac.uk.

BMJ Open
|August 30, 2019
PubMed

Insights

Developing new diagnostic criteria for pediatric psoriasis is crucial for timely treatment. This study aims to create history and examination-based criteria to accurately distinguish childhood psoriasis from other scaly rashes.

Area of Science:

  • Dermatology
  • Pediatric Medicine
  • Clinical Diagnostics

Background:

  • Diagnosing psoriasis in children presents significant challenges.
  • Early and accurate diagnosis is vital for appropriate treatment and monitoring of pediatric psoriasis.
  • Psoriasis in children carries substantial physical, psychological, and quality-of-life burdens.

Purpose of the Study:

  • To develop clinical examination and history-based diagnostic criteria for psoriasis in children.
  • To differentiate pediatric psoriasis from other inflammatory scaly skin conditions.
  • To improve diagnostic accuracy and facilitate timely management of childhood psoriasis.

Main Methods:

  • A consensus study with international psoriasis experts informed the initial criteria development.
  • Children with psoriasis (cases) and other scaly inflammatory skin diseases (controls) were recruited.
  • Diagnostic criteria were assessed by blinded investigators, with dermatologist diagnosis serving as the reference standard.
  • Multivariate logistic regression will be used to identify the best predictive criteria.

Main Results:

  • Sensitivity and specificity of the consensus-derived criteria will be calculated.
  • The study aims to identify the most predictive diagnostic criteria for pediatric psoriasis.
  • Results will be based on a comparison between the developed criteria and dermatologist diagnoses.

Conclusions:

  • The developed diagnostic criteria aim to aid clinicians in accurately identifying psoriasis in children.
  • Improved diagnostic tools can lead to earlier intervention and better management of pediatric psoriasis.
  • This research seeks to reduce the diagnostic delay and associated burdens for children with psoriasis.
Abstract

Keywords:
psoriasis children diagnosis case-control

More Related Videos

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics10:42

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Published on: June 17, 2022

3.4K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Published on: August 11, 2025

472

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
312
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
472
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
310
Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics10:42

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Access to decentralized, low-cost, and high-capacity diagnostics that can be deployed into the community for decentralized testing is critical for combating global health crises. This manuscript describes how to build paper-based diagnostics for viral RNA sequences that can be detected with a portable optical...
3.4K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
508
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
530