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Glucose-responsive Insulinoma with Insulin Hypersecretion Suppressed by Metformin
Kunihisa Hamano1, Kayo Akita2, Yoko Takeuchi1
1Division of Nephrology and Diabetology, Narita Memorial Hospital (Meiyokai Medical Corporation), Japan.
Abstract:
In type 2 diabetes mellitus, metformin suppresses excessive insulin secretion in relation to the intake of glucose. We herein report the case of a 45-year-old man with glucose-responsive insulinoma whose responsive hypoglycemia was alleviated by metformin. The patient had a history of a postprandial loss of consciousness, resulting in hospital admission. He refused surgery and diazoxide administration. A 75-g oral glucose tolerance test after metformin administration revealed the suppression of glucose-responsive insulin hypersecretion and responsive hypoglycemia. Pancreatic head duodenectomy was performed, which alleviated the symptoms. Metformin administration in patients with glucose-responsive insulinoma may therefore be effective for preventing responsive hypoglycemia and hyperinsulinemia.
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