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3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles.

Xiaowen Xu1, Jingzhou Zhao1, Maonan Wang1

  • 1School of Physics and Electronics, Central South University, Changsha, Hunan, 410083, China.

Scientific Reports
|August 30, 2019
PubMed
Summary
This summary is machine-generated.

Three-dimensional (3D) printing enables customized tablet geometries for controlled drug release. Different internal structures like cylinder, horn, and reversed horn models successfully achieved constant, increasing, and decreasing release profiles, respectively.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Biomedical Engineering

Background:

  • Controlled drug release is crucial for therapeutic efficacy and patient compliance.
  • Traditional tablet formulations have limitations in achieving precise and customizable release profiles.
  • 3D printing offers a novel approach for fabricating complex pharmaceutical dosage forms.

Purpose of the Study:

  • To investigate the feasibility of using 3D printed internal geometries for controlled drug release.
  • To design and fabricate different tablet models with specific release characteristics.
  • To evaluate the in vitro drug release performance of these customized formulations.

Main Methods:

  • Design of three distinct tablet models (Cylinder, Horn, Reversed Horn) with internal controlled structures.
  • Fabrication of tablets using fused deposition modeling (FDM) 3D printing.
  • Incorporation of paracetamol (APAP) into gel formulations for tablet injection.
  • In vitro drug release studies to assess release profiles.

Main Results:

  • Successful fabrication of 3D printed tablets with Cylinder, Horn, and Reversed Horn geometries.
  • Demonstrated ability to achieve constant, gradually increasing, and gradually decreasing drug release profiles, respectively.
  • Confirmed that drug release attributes are controllable via internal 3D printed geometry.
  • Observed no residues after in vitro dissolution, indicating complete drug release.

Conclusions:

  • 3D printing allows for the creation of customized tablet formulations with tailored drug release profiles.
  • The designed internal geometries effectively control the release rate of paracetamol.
  • This technology holds significant potential for patient-tailored medicines and improved therapeutic outcomes.