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Updated: Jan 20, 2026

Translational Rabbit Model of Chronic Cardiac Pacing
Published on: January 6, 2023
Update in Cardiac Pacing
Nishant Verma1, Bradley P Knight1
1Division of Cardiology, Department of Medicine, Northwestern University, Feinberg School of Medicine Chicago, IL, US.
Abstract:
Initial efforts to artificially stimulate the heart were borne out of a necessity to prevent catastrophic bradycardic events. The initial pacemaker systems were large, bulky external devices. However, advancements in technology allowed for the development of internally powered, fully implantable devices. Further advancements resulted in more complex, programmable devices, but the overall systems have remained largely unchanged for more than 50 years. The most recent advancements in the field have represented fundamental paradigm shifts in both pacemaker design and the approach to cardiac pacing. These efforts have focused on reducing and eliminating hardware to reduce the risk of complications and to focus on improving cardiac efficiency to improve clinical outcomes. In this article, the authors explore these advances including leadless pacemaker systems, permanent His bundle pacing and advances in the field of cardiac resynchronisation therapy.
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