Recurrent empty follicle syndrome with different stimulation protocols - A case report.

Area of Science:

• Reproductive Endocrinology
• In Vitro Fertilization (IVF)
• Ovarian Physiology

Background:

• Empty Follicle Syndrome (EFS) is a rare cause of infertility characterized by the absence of oocytes in aspirated follicular fluid despite adequate follicular development.
• Recurrent cases pose significant challenges in assisted reproductive technologies, necessitating exploration of management strategies.

Observation:

• A case of recurrent EFS is presented, involving two separate IVF cycles with different stimulation protocols.
• In the second cycle, a 24-hour delay in oocyte aspiration post-second human chorionic gonadotropin (hCG) dose did not result in oocyte retrieval.

Findings:

• Despite interventions including modified protocols and repeat hCG administration, no oocytes were successfully retrieved in either IVF cycle due to genuine EFS.
• The study underscores the limited efficacy of altered protocols or repeat hCG in overcoming genuine EFS.

Implications:

• This case suggests that for genuine EFS, alternative fertility treatments like donor embryo transfer may be the only viable option.
• It highlights the importance of accurate diagnosis and realistic counseling for patients experiencing recurrent EFS.