Chloroquine induced urticaria: A newer adverse effect

Area of Science:

• Tropical medicine
• Pharmacology
• Dermatology

Background:

• Malaria is a significant endemic disease in India, commonly treated with chloroquine, a quinolone-derivative antimalarial.
• Chloroquine is generally considered safe, even during pregnancy, but adverse effects are documented.
• Understanding drug-induced adverse events is crucial for patient safety and effective treatment.

Observation:

• A 30-year-old male diagnosed with malaria presented with fever.
• Immediately following the administration of the first dose of chloroquine, the patient developed urticaria (hives).

Findings:

• This case represents the first documented instance of chloroquine-induced urticaria in an adult patient.
• The urticarial reaction was successfully managed, indicating that prompt recognition and treatment are effective.

Implications:

• Highlights the potential for chloroquine to cause acute hypersensitivity reactions like urticaria, even in adults.
• Emphasizes the importance of vigilance for adverse drug reactions during malaria treatment.
• Suggests the need for further investigation into the immunological mechanisms of chloroquine hypersensitivity.