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Updated: Jan 20, 2026

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Published on: June 6, 2025

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Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension

Marat Fudim1,2, Vanessa L Blumer3, Renato D Lopes4

  • 1Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA. marat.fudim@dm.duke.edu.

Journal of Cardiovascular Translational Research
|August 30, 2019
PubMed

Insights

Hypertension management requires understanding blood volume. This study found wide variations in total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients, with no correlation to systolic blood pressure (SBP).

Area of Science:

  • Cardiology
  • Nephrology
  • Internal Medicine

Background:

  • Volume management is crucial in anti-hypertensive therapy.
  • Specific volume phenotypes in hypertension require further investigation.

Purpose of the Study:

  • To investigate total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients.
  • To determine the correlation between blood volume parameters and systolic blood pressure (SBP).

Main Methods:

  • Radioisotope iodine-131-labeled albumin dilution technique used for blood volume measurements.
  • 95 hypertensive patients from an outpatient cardiology clinic (1998-2003) were included.
  • Blood volume parameters expressed as percentage deviation from ideal volumes.

Main Results:

  • Wide variations observed in TBV (-23% to +28%), PV (-22% to +36%), and RBV (-29% to +37%).
  • No significant correlation found between SBP and TBV (r=-0.03), PV (r=-0.12), or RBV (r=-0.08).

Conclusions:

  • Hypertensive patients exhibit significant heterogeneity in blood volume parameters.
  • Blood volume does not correlate with systolic blood pressure in this cohort.

Keywords:
Blood volume analysisGenderHypertensionRace

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