Developmental enamel defects are associated with early childhood caries: Case-control study
Related Experiment Video
Updated: Jan 20, 2026

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
Patrícia Corrêa-Faria1, Suzane Paixão-Gonçalves2, Maria Letícia Ramos-Jorge3
1Postgraduate Program in Dentistry, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Background:
Knowledge on the association between developmental enamel defects (DED) and early childhood caries (ECC) has importance for the drafting of prevention measures and oral healthcare planning.
Aim:
To compare the frequency of ECC in children with and without DED and verify their association with sociodemographic factors.
Design:
This case-control study was carried out with Brazilian children aged one to five years. The case group made up of 98 children with ECC and the control group was made up of 98 children without ECC. DED were classified in diffuse opacity, demarcated opacity and enamel hypoplasia (Developmental Defects of Enamel Index). Sociodemographic data were collected by a questionnaire answered by parents. Statistical analysis used McNemar's test and logistic regression analyses.
Results:
In the bivariate analysis, ECC was more frequent among children from families with poorer socioeconomic conditions (lower monthly household income [P ≤ .001] and lower maternal schooling [P = .001]) and among those with DED (P ≤ .001). The final logistical model showed that children with DED (OR: 1.94) and a monthly household income less than two Brazilian minimum salaries (OR: 2.24) were more likely to have ECC.
Conclusions:
The occurrence of DED and lower household income were pre-disposing factors for the occurrence of ECC.
Related Concept Videos
08:26Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Explant Culture for Developmental Studies
This video will first introduce the basic principles of explant culture and demonstrate a protocol to...
An Introduction to Developmental Genetics
This video reviews seminal research in the field of developmental biology, including the identification of specific genes that control various embryonic processes. An introduction to the major questions asked...
An Introduction to Molecular Developmental Biology
This video will review a brief history of the study of molecular events during development. Next, key questions asked by molecular...
07:57Sampling and Pretreatment of Tooth Enamel Carbonate for Stable Carbon and Oxygen Isotope Analysis
An Introduction to Developmental Neurobiology