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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Window of Opportunity trials for biomarker discovery in breast cancer
Monica Arnedos1,2, Matthieu Roulleaux Dugage1, Jose Perez-Garcia3,4
1Department of Medical Oncology.
Purpose Of Review:
Window of Opportunity (WOO) studies have gain their place in current clinical and translational research in breast cancer patients. This review provides current information and future applications of this specific type of research.
Recent Findings:
So far, WOO trials in breast cancer patients have demonstrated their utility in breast cancer research as: first they allow administering a treatment for a short period of time to treatment-naïve patients whose tumors have not developed mechanisms of resistance or heterogeneity because of previous therapies. Second, it brings a unique opportunity for translational research providing easy access to tumor tissue in order to evaluate antitumor effect from initial biopsy and from surgical resection specimen. They provide the perfect scenario for biomarker discovery and validation in an efficient and timely manner and valuable information about drug pharmacodynamics. Several issues need to be contemplated when designing and performing this type of trials including choice of a biological surrogate endpoint of efficacy as standard clinical activity endpoints are not feasible.
Summary:
Despite some limitations like the absence of information about secondary mechanisms of resistance, WOO trials represent an important support for drug development and biomarker discovery in breast cancer patients.
Insights
Window of Opportunity (WOO) studies in breast cancer research offer a unique window for drug development and biomarker discovery. These trials provide early tumor access for evaluating treatment effects and pharmacodynamics in treatment-naïve patients.
Area of Science:
- Oncology
- Translational Research
- Clinical Trials
Background:
- Window of Opportunity (WOO) studies are increasingly recognized in breast cancer research.
- These trials offer a distinct approach to investigating novel therapies.
Purpose of the Study:
- To review current information and future applications of WOO studies in breast cancer.
- To highlight the utility of WOO trials in clinical and translational research.
Main Methods:
- WOO trials involve administering treatment for a short duration to treatment-naïve patients.
- Tumor tissue is accessible for evaluating antitumor effects via biopsy and resection specimens.
- These studies facilitate biomarker discovery, validation, and assessment of drug pharmacodynamics.
Main Results:
- WOO trials allow evaluation of treatments before resistance mechanisms develop.
- They provide valuable insights into drug pharmacodynamics and antitumor effects.
- Biomarker discovery and validation are efficiently achieved.
Conclusions:
- WOO studies are crucial for drug development and biomarker discovery in breast cancer.
- Despite limitations like lack of secondary resistance data, they support early-phase research.
- Careful design, including selection of surrogate endpoints, is essential for WOO trials.
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