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Related Experiment Video

Updated: Jan 20, 2026

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
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Cardiovascular risk reduction with icosapent ethyl.

Parth N Patel1, Siddharth M Patel, Deepak L Bhatt

  • 1Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, Massachusetts, USA.

Current Opinion in Cardiology
|August 30, 2019
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Summary

Icosapent ethyl significantly reduced cardiovascular events in high-triglyceride patients on statins. This omega-3 fatty acid treatment addresses residual risk for atherosclerotic cardiovascular disease (ASCVD).

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Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Residual risk for atherosclerotic cardiovascular disease (ASCVD) persists despite optimal low-density lipoprotein cholesterol (LDL-C) levels.
  • Elevated triglycerides are an independent ASCVD risk factor, though previous triglyceride-lowering therapies showed limited benefit in the statin era.

Purpose of the Study:

  • To evaluate the efficacy of icosapent ethyl in reducing cardiovascular events in patients with high triglycerides and residual ASCVD risk.
  • To investigate the role of omega-3 fatty acids beyond triglyceride lowering in cardiovascular risk reduction.

Main Methods:

  • The REDUCE-IT trial enrolled patients with high triglycerides on statin therapy.
  • Patients received icosapent ethyl, a highly purified omega-3 fatty acid (OM3FA) ethyl ester.

Main Results:

  • Icosapent ethyl demonstrated a 25% relative risk reduction in the primary composite cardiovascular endpoint (HR 0.75, 95% CI 0.68–0.83; P < 0.00000001).
  • A 30% relative risk reduction in total ischemic events was observed (P < 0.00000000036).

Conclusions:

  • Icosapent ethyl effectively decreases residual cardiovascular risk in patients with elevated triglycerides.
  • The benefits of icosapent ethyl may extend beyond simple triglyceride lowering, necessitating its clinical application in high-risk populations.