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Pediatric Exposures Reported to the Toxicology Investigators Consortium, 2010-2015.

Neil M Desai1, Rakesh D Mistry, Lina Brou2

  • 1From the Section of Pediatric Emergency Medicine, British Columbia Children's Hospital, Vancouver, BC, Canada.

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|August 30, 2019
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Summary

Pediatric toxicology consultations increased significantly from 2010 to 2015, with analgesics being the most common exposure. Understanding these trends is crucial for effective hospital preparedness and treatment strategies.

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Area of Science:

  • Medical Toxicology
  • Pediatric Emergency Medicine
  • Public Health Surveillance

Background:

  • Poisoning is a leading cause of fatal injuries in children.
  • Effective hospital and provider readiness relies on accurate data of pediatric poisoning patterns and treatments.
  • Surveillance data is essential for age-specific clinical exposure and therapeutic modality understanding.

Purpose of the Study:

  • To characterize trends in clinically significant pediatric toxic exposures.
  • To analyze the management and therapeutic modalities employed for these exposures.
  • To inform hospital-level planning and provider education.

Main Methods:

  • Retrospective review of the Toxicology Investigators Consortium (ToxIC) Registry.
  • Analysis of pediatric cases (18 years or younger) from January 1, 2010, to December 31, 2015.
  • Inclusion of data on demographics, exposure details, survival, and treatments like antidotes and decontamination.

Main Results:

  • A notable increase in pediatric toxicology consultations from 2010 to 2015 (23.7% to 29.9%).
  • Adolescents and females comprised the majority of exposures, with intentional ingestions being most common.
  • Analgesics were the most frequent exposure agent; N-acetylcysteine was the most used antidote. Geographic variations in exposures and treatments were observed.

Conclusions:

  • Toxicology consultations for pediatric exposures have risen substantially.
  • Identifying key pediatric exposures, common therapies, and geographic patterns is vital.
  • This understanding supports facility planning, pharmacy stocking, and enhanced provider education.