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Updated: Jan 20, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
New insights and perspectives on the genetics of obsessive-compulsive disorder
Gwyneth Zai1, Csaba Barta, Danielle Cath
1Neurogenetics Section, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Department of Psychiatry Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary Groningen University and University Medical Center Groningen, Department of Psychiatry, The Netherlands Drenthe Mental Health Institute, Department of Specialist Training, The Netherlands Department of Psychiatry, University of New South Wales, Sydney, Australia & Academic Unit of Child Psychiatry South West Sydney, Ingham Institute and Liverpool Hospital, Sydney, Australia Massachusetts General Hospital and Harvard University Medical School, Boston, MA, USA Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Switzerland Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland.
Abstract:
Psychiatric genetic research has exploded in search of polygenic risk factors over the past decade, but because of the complexity and heterogeneity of mental illnesses, using the current understanding of the genome has not reached the conclusion of finding a cause for psychiatric disorders. Obsessive-compulsive disorder is a relatively common and often debilitating neuropsychiatric disorder that has not been the primary focus in psychiatric research. Clinicians and researchers who have dedicated to investigate the genetics of obsessive-compulsive disorder have detected a strong genetic involvement. This review will provide an update and a new perspective on the current understanding of the genetics of obsessive-compulsive disorder, which includes epidemiological data, family and twins studies, candidate gene studies, genome-wide association studies, copy-number variants, imaging genetics, epigenetics, and gene-environment interaction.
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