Living cell-based regenerative medicine technologies for periodontal soft tissue augmentation

Area of Science:

• Periodontal regeneration
• Tissue engineering
• Cellular therapy

Background:

• Cultivating human cells in scaffolding matrices is gaining popularity for periodontal wound healing.
• Living cellular constructs offer alternatives to autogenous soft tissue grafts.
• Advantages include reduced patient morbidity and unlimited graft availability.

Purpose of the Study:

• To review soft tissue augmentation and root coverage procedures using bioengineered living cellular therapy.
• To highlight clinical, esthetic, and patient-related outcomes.

Main Methods:

• Review of current literature on bioengineered living cellular therapy in periodontics.
• Analysis of studies on fibroblast and keratinocyte constructs.
• Evaluation of outcomes in soft tissue augmentation and root coverage.

Main Results:

• Living cellular constructs show promise as alternatives to autogenous grafts.
• Comparable esthetic outcomes are achievable.
• Reduced patient morbidity is a significant benefit.

Conclusions:

• Bioengineered living cellular therapy is a viable option for periodontal regeneration.
• Further research can optimize clinical and esthetic outcomes.
• Patient-centered benefits are a key advantage.