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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
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Telomeres are essential for chromosome stability and the telomere G-overhang structure is essential for telomerase-mediated telomere maintenance. We have recently adopted two methods for detecting the telomere G-overhang structure in Trypanosoma brucei, which are native in-gel hybridization and ligation-mediated primer extension, which will be...
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This protocol illustrates a chemically induced protein dimerization system to create condensates on chromatin.  The formation of promyelocytic leukemia (PML) nuclear body on telomeres with chemical dimerizers is demonstrated. Droplet growth, dissolution, localization and composition are monitored with live cell imaging, immunofluorescence (IF) and fluorescence in situ hybridization...
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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence12:08

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An accurate, short, sophisticated and cheap method is described that assesses telomere length in multiple tissues and species using qRT-PCR. In addition, we will describe a simple assay to assess telomerase activity as a complementary backbone test for telomere...
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Here we present a protocol for the measurement of relative telomere length (TL) using the monochrome multiplex quantitative polymerase chain reaction (MMqPCR) assay. The MMqPCR assay is a repeatable, efficient, and cost-effective method for measuring TL from human DNA in population-based...
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Related Experiment Video

Updated: Jan 20, 2026

Telomeres,Telomerase and Shelterin
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Telomere length determinants in childhood.

Vesna Gorenjak1, Alexandros M Petrelis1, Maria G Stathopoulou1

  • 1University of Lorraine, Inserm, IGE-PCV, Nancy, France.

Clinical Chemistry and Laboratory Medicine
|August 30, 2019
PubMed
Summary

Telomere length (TL) is established in childhood, influenced by intrauterine factors and early growth. Adult environments have less impact on TL than previously thought, highlighting childhood as a critical period.

Keywords:
attritionchildrendeterminantsdynamicsgeneticstelomere length

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Area of Science:

  • Pediatrics
  • Genetics
  • Cell Biology

Background:

  • Telomere length (TL) is a biomarker for aging and disease.
  • Childhood TL research is less extensive than adult studies.
  • TL is influenced by genetics and environmental factors.

Purpose of the Study:

  • To review current knowledge on telomere dynamics in early childhood.
  • To identify factors affecting newborn TL.
  • To highlight research gaps in telomere regulation and biomarker potential.

Main Methods:

  • Literature review of studies on childhood telomere biology.
  • Analysis of factors influencing intrauterine and early childhood TL.
  • Synthesis of findings on telomere shortening rates.

Main Results:

  • TL is largely determined in childhood, with significant inter-individual variation at birth.
  • Intrauterine development and early growth significantly impact newborn TL.
  • Telomere shortening is rapid in early childhood and stabilizes in adulthood.

Conclusions:

  • Childhood is a critical window for TL determination.
  • Understanding childhood TL is crucial for its use as a diagnostic biomarker.
  • Further research is needed to fully elucidate telomere regulation and application.