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Related Experiment Videos

Induction of ovulation--past, present and future.

R Jewelewicz1, P R Gindoff

  • 1Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, N.Y.

Gynecologic and Obstetric Investigation
|January 1, 1988
PubMed
Summary

Ovulation induction has advanced significantly since the 1960s with medications like clomiphene citrate and gonadotropins. Future research may enable ovulation induction through direct central nervous system manipulation.

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Area of Science:

  • Reproductive endocrinology
  • Neuroendocrinology

Background:

  • Ovulation induction attempts date back to the 1920s.
  • Major advancements occurred in the 1960s with clomiphene citrate and gonadotropins.
  • Further progress in the 1970s and 1980s introduced bromocriptine and pulsatile GnRH.

Purpose of the Study:

  • To review the historical development of ovulation induction methods.
  • To highlight current and emerging strategies in ovulation induction.

Main Methods:

  • Review of historical data and clinical advancements in ovulation induction therapies.
  • Evaluation of current adjuncts like 'pure' FSH and GnRH agonists with HMG.
  • Exploration of potential future neuroendocrine manipulation techniques.

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Main Results:

  • Clomiphene citrate and gonadotropins marked a breakthrough in the 1960s.
  • Bromocriptine and pulsatile GnRH represented further progress in subsequent decades.
  • Current research focuses on 'pure' FSH and GnRH agonists as HMG adjuncts.

Conclusions:

  • Ovulation induction has evolved significantly through pharmacological interventions.
  • Understanding neuroendocrine control offers potential for novel, direct induction methods.
  • Future ovulation induction may involve direct central nervous system manipulation.