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Related Experiment Videos

The pituitary-thyroid axis in acromegaly.

P C Eskildsen1, A Kruse, C Kirkegaard

  • 1Medical Endocrinological Department F, Fredericksborg County Hospital, Hillerød, Denmark.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|December 1, 1988
PubMed
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Acromegaly patients show subtle central hypothyroidism with lower TSH and T4 levels, potentially due to somatostatin. Euthyroidism is maintained by increased T4 to T3 conversion.

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Thyroid Function

Background:

  • Acromegaly, a condition caused by excess growth hormone (GH), can affect the pituitary-thyroid axis.
  • Understanding thyroid function in acromegaly is crucial for managing patient health and preventing complications.

Purpose of the Study:

  • To evaluate the pituitary-thyroid axis in patients with acromegaly.
  • To investigate serum concentrations of thyroid hormones and pituitary hormones in acromegalic patients compared to healthy controls.

Main Methods:

  • Measured serum concentrations of total and free thyroxine (T4), triiodothyronine (T3), reverse T3 (rT3), thyrotropin (TSH), growth hormone (GH), and prolactin (PRL).
  • Stimulated TSH, GH, and PRL release using thyrotropin-releasing hormone (TRH) in 12 acromegalic patients and 40 healthy controls.

Related Experiment Videos

  • Utilized an ultrasensitive TSH measurement method (IRMA).

    • Main Results:

    • Acromegalic patients exhibited significantly lower basal serum TSH and total T4 levels compared to controls, suggesting central hypothyroidism.
    • Serum T3 levels were normal, but reverse T3 (rT3) levels were significantly decreased.
    • A positive correlation was observed between TSH and GH responses to TRH, indicating potential central suppression of both hormones.

    Conclusions:

    • Acromegaly may be associated with central hypothyroidism, characterized by suppressed TSH and T4 levels.
    • The findings suggest that somatostatin might play a role in suppressing TSH and GH secretion in acromegalic subjects.
    • Euthyroidism in these patients could be maintained through enhanced extrathyroidal conversion of T4 to T3.