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Updated: Jan 20, 2026
Quantification of Helicobacter pylori Load in an Infected Mouse Stomach
Association between Helicobacter pylori infection and arterial stiffness: Results from a large cross-sectional study
Ji Min Choi1, Seon Hee Lim1, Yoo Min Han1
1Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea.
Insights
Chronic Helicobacter pylori (Hp) infection is linked to increased arterial stiffness, a cardiovascular disease predictor. This finding suggests Hp infection may contribute to the development of atherosclerosis and related cardiovascular events.
Area of Science:
- Cardiovascular Science
- Infectious Disease Epidemiology
- Vascular Biology
Background:
- Chronic systemic inflammation is a key factor in atherosclerosis development.
- The impact of chronic Helicobacter pylori (Hp) infection on arterial stiffness, a cardiovascular event predictor, is not well understood.
- Arterial stiffness is an indicator of cardiovascular risk.
Purpose of the Study:
- To investigate the association between Hp infection and arterial stiffness in asymptomatic healthy individuals.
- To evaluate if Hp infection is an independent risk factor for increased arterial stiffness.
- To determine the relationship between Hp seropositivity and cardiovascular parameters.
Main Methods:
- The study included 2,251 subjects who underwent simultaneous cardio-ankle vascular index (CAVI) and anti-Hp IgG antibody evaluations.
- Demographic, metabolic, and cardiovascular parameters were compared between Hp-seropositive and Hp-seronegative groups.
- Multivariable logistic regression analysis was used to assess the association of Hp-seropositivity and cardiovascular risk factors with arterial stiffness (CAVI).
Main Results:
- Of 2,251 subjects, 58.9% were Hp-seropositive.
- Hp-seropositive individuals had significantly higher median age, systolic blood pressure, and LDL-cholesterol levels.
- Median CAVI values and the proportion of subjects with high CAVI (≥ 8) were significantly higher in the Hp-seropositive group.
- Hp-seropositivity, age, BMI, waist circumference, smoking, hypertension, diabetes mellitus, and dyslipidemia were significantly associated with high CAVI.
Conclusions:
- Hp-seropositivity was significantly associated with increased arterial stiffness.
- The findings suggest that Hp infection may play a role in the pathogenesis of cardiovascular diseases.
- Further research is warranted to explore the mechanisms linking Hp infection to vascular dysfunction.
Background:
Chronic systemic inflammation is an important causative factor in the pathogenesis of atherosclerosis. However, the effect of chronic Helicobacter pylori (Hp) infection on arterial stiffness, a predictor of cardiovascular events, remains unclear. We evaluated the association between Hp infection and arterial stiffness in asymptomatic healthy individuals.
Methods:
Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI). We included subjects who underwent CAVI and anti-Hp IgG antibody evaluations, simultaneously, between March 2013 and July 2017. Demographic characteristics and metabolic and cardiovascular parameters were compared with respect to anti-Hp IgG antibody status. Multivariable logistic regression analyses were performed to determine the effect of Hp-seropositivity and conventional cardiovascular risk factors on arterial stiffness.
Results:
Of 2,251 subjects, 1,326 (58.9%) were included in the Hp-seropositive group. Median age (P < 0.001) and systolic blood pressure (P = 0.027) were significantly higher in the Hp-seropositive than in the Hp-seronegative group. Levels of LDL-cholesterol were significantly higher in the Hp-seropositive than in the Hp-seronegative group (P = 0.016). Other serum metabolic parameters were not significantly different between the two groups. The median CAVI value and the proportion of subjects with a CAVI ≥ 8 were significantly higher in the Hp-seropositive than in the Hp-seronegative group (both P < 0.001). On multivariable logistic regression analyses, Hp-seropositivity, age, body mass index, waist circumference, smoking, hypertension, diabetes mellitus, and dyslipidemia were significantly associated with high CAVI values. In the subgroup analysis conducted according to age group, a tendency towards an increased association between Hp-seropositivity and CAVI was observed with increasing age, even though the difference did not reach the statistical significance.
Conclusions:
Hp-seropositivity was significantly associated with arterial stiffness. Hp infection may contribute to the development of cardiovascular diseases.
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