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Related Experiment Video

Updated: Jan 20, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Using pH-Activable Carbon Nanoparticles as Cell Imaging Probes.

Honggui Lin1,2, Jianlong Su1, Ranjith Kumar Kankala1

  • 1Department of Chemical Engineering & Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.

Micromachines
|August 31, 2019
PubMed
Summary
This summary is machine-generated.

We developed novel pH-activable carbon nanoparticles (CNPs) using a green synthesis method. These biocompatible CNPs are effective for cell imaging and can induce tumor cell death by responding to pH changes.

Keywords:
carbon nanoparticlescell imagingcellular internalizationpH responsiveness

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Carbon nanoparticles (CNPs) are increasingly utilized in biomedical applications due to their unique optical and electronic properties.
  • Developing responsive nanomaterials for targeted cellular imaging and therapy remains a significant challenge in nanomedicine.

Purpose of the Study:

  • To fabricate innovative pH-activable carbon nanoparticles (CNPs) for enhanced cell imaging and therapeutic applications.
  • To investigate the pH responsiveness, biocompatibility, and cellular internalization of synthesized CNPs.

Main Methods:

  • Microwave-assisted green synthesis of CNPs using urea and citric acid.
  • Characterization of CNP properties, including pH responsiveness (1.0–4.6 and 4.6–9.0), charge modification, and diameter.
  • Evaluation of CNPs in cell imaging and assessment of their effect on tumor cell death.

Main Results:

  • Successfully synthesized pH-activable CNPs with excellent biocompatibility.
  • Demonstrated pH-dependent charge modification and diameter control of CNPs.
  • Observed enhanced cellular internalization and tumor cell death mediated by CNPs due to pH responsiveness.

Conclusions:

  • The developed CNPs serve as stable sensors for cell imaging across a wide pH range (4.6–9.0) and can detect intracellular pH changes (1.0–4.6).
  • The pH-activable CNPs show potential for advanced biological labeling, bioimaging, and drug delivery applications.
  • These findings highlight the promise of CNPs for targeted cancer therapy and diagnostics.