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[Granulocyte dysfunction in transcobalamin II deficiency].

R Seger, A Wildfeuer, M Fràter-Schröder

    Schweizerische Medizinische Wochenschrift
    |September 29, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Congenital transcobalamin II deficiency impairs granulocyte antibacterial function. Supplementation with hydroxocobalamin or leucovorin temporarily restored this immune cell activity, suggesting a link to cobalamin and folate coenzymes.

    Area of Science:

    • Immunology
    • Hematology
    • Nutritional Biochemistry

    Background:

    • Congenital transcobalamin II (TC II) deficiency is a rare genetic disorder affecting vitamin B12 absorption and transport.
    • Impaired vitamin B12 metabolism can lead to deficiencies in essential coenzymes, impacting cellular functions.
    • Granulocytes play a critical role in the innate immune system, particularly in combating bacterial infections.