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Updated: Jan 20, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Orthobiologics.

Tenaya A West¹, Mitzi L Williams²

¹Kaiser San Francisco Bay Area Foot and Ankle Residency Program, Department of Orthopedics and Podiatric Surgery, Kaiser Foundation Hospitals, 3600 Broadway, Oakland, CA 94611, USA.

Clinics in Podiatric Medicine and Surgery

|August 31, 2019

Summary

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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

This article describes the generation of an orthotopic mouse model of human pleural mesothelioma by implantation of H2052/484 mesothelioma cells into the pleural cavity of immunocompromised athymic mice. The longitudinal monitoring of the development of intrapleural tumors was assessed by non-invasive multimodal [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography...

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Orthobiologics show promise in sports medicine but often lack clinical evidence. Evidence-based use and further research are crucial for safe and effective application in foot and ankle surgery.

Area of Science:

Orthopedic Surgery
Sports Medicine
Regenerative Medicine

Background:

Orthobiologics are increasingly used in musculoskeletal and sports medicine.
Many commercially available orthobiologic products lack robust clinical evidence.
Premature adoption may lead to adverse outcomes and increased healthcare costs.

Purpose of the Study:

To review the clinical evidence supporting the use of common orthobiologics.
To evaluate the efficacy of orthobiologics in treating foot and ankle pathology.
To promote evidence-based medicine in the application of orthobiologics.

Main Methods:

Literature review of clinical studies on orthobiologics.
Analysis of evidence for common orthobiologic agents.

Keywords:

Allograft Autograft Bone substitutes Foot and ankle Foot surgery Orthobiologics PRP

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Last Updated: Jan 20, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Focus on applications in foot and ankle conditions.

Main Results:

Significant interest exists in orthobiologics for sports injuries.
Clinical evidence for many marketed orthobiologic products is limited.
The review highlights the need for critical evaluation of available data.

Conclusions:

Judicious use of orthobiologics is essential.
Practicing evidence-based medicine is paramount.
Continued research is vital to improve surgical outcomes with orthobiologics.