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Advances in T-cell Immunotherapies.

David F Stroncek1, Opal Reddy1, Steven Highfill1

  • 1Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Center for Cellular Engineering, 10 Center Drive, MSC-1184, Building 10, Room 1C711, Bethesda, MD 20892-1184, USA.

Hematology/Oncology Clinics of North America
|August 31, 2019
PubMed
Summary

Cell therapies, particularly T-cell immunotherapies, are crucial in hematology and oncology. This review covers the clinical use and manufacturing of these advanced adoptive cell therapies.

Keywords:
Cancer immunotherapyCell processingChimeric antigen receptor T cellsDonor lymphocyte infusionsTumor-infiltrating lymphocytesVirus-specific T cells

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Area of Science:

  • Hematology and Oncology
  • Cell Therapy Manufacturing
  • Immunotherapy

Background:

  • Cell therapies are integral to modern clinical hematology and oncology.
  • Cell therapy laboratories originated from processing ABO-incompatible marrow grafts.
  • These labs now produce diverse cell and gene therapies.

Purpose of the Study:

  • To review the clinical applications of adoptive cell therapies.
  • To describe the manufacturing methods for key T-cell immunotherapies.
  • To provide an overview of current cell therapy practices.

Main Methods:

  • Review of clinical literature on cell therapies.
  • Analysis of manufacturing processes for T-cell immunotherapies.
  • Synthesis of information on donor lymphocyte infusions, tumor-infiltrating lymphocytes, T-cell receptor-engineered T cells, chimeric antigen receptor T cells, and virus-specific T cells.

Main Results:

  • T-cell immunotherapies represent a significant advancement in cancer treatment.
  • Diverse manufacturing techniques are employed for various adoptive cell therapies.
  • Established clinical applications exist for multiple T-cell-based treatments.

Conclusions:

  • Adoptive cell therapies, especially T-cell immunotherapies, are vital in clinical practice.
  • Understanding manufacturing processes is key to their successful clinical implementation.
  • Continued development in cell therapy holds promise for hematology and oncology.