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Updated: Jan 20, 2026

Application of Hemostatic Devices in Laparoscopic Hepatectomy
Published on: April 19, 2022
The Development and Impact of Hemostatic Stewardship Programs.
Kathryn E Dane1, Michael B Streiff2, John Lindsley1
1Department of Pharmacy, The Johns Hopkins Hospital, 600 North Wolfe Street, Carnegie Building, Suite 180, Baltimore, MD 21287, USA.
New clotting factor concentrates and anticoagulation antidotes increase care complexity and cost. A multidisciplinary hemostatic stewardship program is vital for optimizing these resources and managing patient care effectively.
Area of Science:
- Hematology
- Pharmacology
- Healthcare Management
Background:
- Recent approvals of novel clotting factor concentrates and anticoagulation antidotes have introduced significant complexities in patient management.
- The increasing availability of these agents necessitates careful consideration of their optimal use to ensure efficacy and safety.
- Rising healthcare costs associated with these advanced therapies underscore the need for efficient resource allocation.
Purpose of the Study:
- To outline a strategic approach for the stewardship of clotting factor concentrates.
- To detail methods for optimizing the use of anticoagulation antidotes.
- To address the increasing complexity and cost of care related to hemostatic agents.
Main Methods:
- Implementation of a multidisciplinary hemostatic stewardship program.
- Development of guidelines for the appropriate selection and administration of clotting factor concentrates.
- Establishment of protocols for the timely and effective use of anticoagulation antidotes.
Main Results:
- Improved utilization of hemostatic resources.
- Enhanced patient safety through appropriate therapy selection.
- Potential for cost savings through optimized drug management.
Conclusions:
- A multidisciplinary hemostatic stewardship program is essential for managing new clotting factor concentrates and anticoagulation antidotes.
- Effective stewardship can mitigate the increased complexity and cost associated with these critical care resources.
- This approach ensures optimal patient outcomes and responsible healthcare resource utilization.
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