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Acupuncture in a Rat Model of Asthma
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New Treatments for Asthma.

Jenny Huang1, Milind Pansare2

  • 1Division of Allergy and Immunology, Department of Pediatrics,Children's Hospital of Michigan, Suite #4022, 4th Floor, 3950 Beaubien Boulevard, Detroit, MI 48201, USA.

Pediatric Clinics of North America
|August 31, 2019
PubMed
Summary

New biologic therapies effectively treat T2 high asthma, but T2 low asthma management remains difficult. Current asthma guidelines require updates to include these advanced therapeutic options for better patient outcomes.

Keywords:
Asthma endotypesBiologicsBronchial thermoplastyLong-acting antimuscarinic agentsSevere asthma

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Area of Science:

  • Pulmonology
  • Immunology
  • Pharmacology

Background:

  • Asthma is a prevalent, complex chronic airway disease with a significant burden of uncontrolled cases.
  • Recent advancements include biologic therapies targeting specific asthma phenotypes.

Purpose of the Study:

  • To review the current landscape of asthma therapeutics.
  • To highlight the challenges in managing T2 low asthma.
  • To emphasize the need for updated clinical guidelines.

Main Methods:

  • Literature review of recent asthma research.
  • Analysis of treatment efficacy for different asthma phenotypes.
  • Evaluation of current clinical practice guidelines.

Main Results:

  • Biologic therapies demonstrate efficacy in T2 high asthma.
  • Effective treatment strategies for T2 low asthma are still limited.
  • Existing guidelines do not fully incorporate novel therapeutic options.

Conclusions:

  • T2 high asthma can be effectively managed with new biologic agents.
  • T2 low asthma presents ongoing therapeutic challenges.
  • Asthma management guidelines must be updated to reflect advancements in biologics and other novel therapeutics.