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Quantifying the Frequency of Tumor-propagating Cells Using Limiting Dilution Cell Transplantation in Syngeneic Zebrafish
08:01

Quantifying the Frequency of Tumor-propagating Cells Using Limiting Dilution Cell Transplantation in Syngeneic Zebrafish

Published on: July 14, 2011

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[Cancer cell transplantation in zebrafish: From translational research to personalized medicine]

Ludivine Raby1, Pamela Völkel2, Xuefen Le Bourhis1

  • 1Inserm U908, Cell Plasticity & Cancer, 59000 Lille, France; University of Lille, 59000 Lille, France.

Bulletin Du Cancer
|August 31, 2019
PubMed

Insights

Zebrafish (Danio rerio) models enable cancer research by allowing in vivo study of tumor development and drug efficacy. This approach aids personalized medicine by testing patient-derived cells for tailored cancer therapies.

Area of Science:

  • Developmental Biology
  • Cancer Research
  • Pharmacology

Background:

  • Zebrafish (Danio rerio) are increasingly utilized as a model organism in cancer research.
  • Cancer cell transplantation in zebrafish offers a platform for studying tumorigenesis and therapeutic efficacy.
  • This model is valuable for investigating cellular and molecular events in cancer development.

Purpose of the Study:

  • To review the zebrafish transplantation model for cancer research.
  • To highlight its application in studying cancer development.
  • To discuss its utility in drug discovery and personalized medicine.

Main Methods:

  • Utilizing zebrafish as an in vivo model for cancer studies.
  • Employing cancer cell transplantation techniques in zebrafish.
  • Applying xenotransplantation with patient-derived cells for personalized medicine.

Main Results:

  • Zebrafish models facilitate the study of tumorigenesis and molecular events.
  • The model allows for in vivo evaluation of therapeutic molecule efficacy.
  • Xenotransplantation in zebrafish supports the identification of personalized therapeutic strategies.

Conclusions:

  • The zebrafish transplantation model is a powerful tool for cancer research.
  • It aids in understanding cancer development and evaluating drug responses.
  • This model contributes to advancing personalized cancer medicine and drug discovery.
Keywords:
CancerCribles de moléculesMolecule screensPatient-derived xenograftsPoisson zèbreTransplantationXénogreffes dérivées de patientsZebrafish

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