Related Experiment Video
Updated: Jan 20, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
Childhood Adversity and Associated Psychosocial Function in Adolescents with Complex Trauma
Sarah J Beal1,2, Twila Wingrove3, Constance A Mara1,2
1Department of Pediatrics, University of Cincinnati College of Medicine, 3230 Eden Ave, Cincinnati, OH 45267 USA.
Background:
Childhood adversity is linked to a number of adult health and psychosocial outcomes; however, it is not clear how to best assess and model childhood adversity reported by adolescents with known maltreatment exposure.
Objective:
This study sought to identify an empirically-supported measurement model of childhood adversity for adolescents in child protective custody and associations among childhood adversity and adolescent outcomes.
Methods:
Self-report survey data assessed childhood adversity and adolescent outcomes, including psychological wellbeing, quality of life, and substance use, in 151 adolescents ages 16 to 22 in protective custody with a documented maltreatment history.
Results:
Findings suggest that, among youth with complex trauma histories, it is important to distinguish among risk related to unexpected tragedy (e.g., natural disaster, parental divorce), family instability (e.g., parental substance abuse or mental health concerns), and family violence (e.g., physical or sexual abuse). Family violence was associated with poorer psychological wellbeing and quality of life, while family instability was associated with cigarette and marijuana use.
Conclusions:
Among adolescents with complex trauma histories, childhood adversity assessments reflect multiple domains of adversity, each of which are differentially related to adolescent risks. Properly assessing childhood adversity in adolescents with complex trauma histories may help target interventions for specific risks (e.g., substance use) based on which types of childhood adversity youth have been exposed to.
Related Concept Videos
07:06Chronic Social Defeat Stress in Early Adolescent Male Mice
06:15A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
07:15Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
06:39Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
07:51Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Cognitive Development During Adolescence

