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Updated: Jan 20, 2026

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks
Published on: February 10, 2023
Synthesis of a [6]rotaxane with singly threaded γ-cyclodextrins as a single stereoisomer
Jason Yin Hei Man1, Ho Yu Au-Yeung1
1Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.
Abstract:
A series of hetero [4]-, [5]- and [6]rotaxanes containing both cucurbit[6]uril (CB[6]) and γ-cyclodextrin (γ-CD) as the macrocyclic components have been synthesized via a threading-followed-by-stoppering approach. Due to the orthogonal binding of CB[6] to ammonium and γ-CD to biphenylene/tetra(ethylene glycol), the [n]rotaxanes display a specific sequence of the interlocked macrocycles. In addition, despite of the asymmetry of γ-CD with respect to the orthogonal plane of the axle, only one stereoisomer of the [6]rotaxane was obtained.
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