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Updated: Jan 20, 2026
In Vitro Measurement of α-Galactosidase A and Acid α-Glucosidase Enzyme Activity
Plant Enzymes Decrease Prostate Cancer Cell Numbers and Increase TNF-α In Vivo: A Possible Role in Immunostimulatory
Yeun-Hwa Gu1, Takenori Yamashita2, Hajime Yamamoto2,3
1Department of Radiological Science, Faculty of Health Science, Junshin Gakuen University, Fukuoka, Japan.
Plant Enzyme Validux (PEV) shows anticancer and radioprotective effects in mice. It suppressed oncogenes, reduced oxidative stress, and boosted immune cells, suggesting its potential as a supplement during cancer radiotherapy.
Area of Science:
- Biochemistry
- Immunology
- Oncology
Background:
- Lifestyle diseases are rising due to increased caloric intake and Western diets.
- Plant Enzyme Validux (PEV) is being investigated for its potential health benefits.
Purpose of the Study:
- To evaluate the anticancer and immunostimulatory effects of PEV.
- To assess PEV's radioprotective properties in a mouse model.
Main Methods:
- Male C3H mice were divided into Control, PEV only, 6Gy irradiation only, and PEV + 6Gy groups.
- PEV was administered orally daily for 14 days before irradiation.
- Anticancer actions, immunostimulatory effects, and radioprotective effects were analyzed.
Main Results:
- PEV treatment suppressed oncogenes and increased TNF-α, indicating antitumor activity.
- PEV reduced oxidative stress and lipid peroxidation.
- PEV demonstrated radioprotective effects by blocking radiation-induced free radicals and increased white blood cells and T lymphocytes.
Conclusions:
- PEV exhibits anticancer and immunostimulatory effects.
- PEV possesses radioprotective properties, potentially beneficial during radiotherapy.
- PEV may serve as a radioprotective supplement for tumor treatment.
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