Wound Photobiomodulation Treatment Outcomes in Animal Models

Area of Science:

• Veterinary Medicine
• Biomedical Engineering
• Regenerative Medicine

Background:

• Photobiomodulation (PBM) offers expanding therapeutic possibilities in human medicine.
• Integrating PBM, specifically low-level laser therapy (LLLT), into veterinary practice is of significant interest.
• Understanding optimal parameters for PBM in animals is crucial for its clinical adoption.

Purpose of the Study:

• To review and analyze treatment outcomes of LLLT in various animal models with open or closed wounds.
• To identify similarities and effective laser parameters across different studies.
• To determine the potential of LLLT for wound healing in veterinary medicine.

Main Methods:

• A systematic literature search was conducted to identify LLLT studies involving diverse animal models.
• Studies were compared based on laser parameters and reported treatment outcomes.
• Focus was placed on identifying correlations between specific parameters and positive wound healing results.

Main Results:

• Daily laser exposure within the 600-800 nm wavelength range demonstrated the most consistent positive outcomes in rodent wound healing studies.
• Results varied across different animal models, indicating a need for species-specific parameter optimization.
• Inconsistent findings were noted in rabbit, canine, and equine models, highlighting research gaps.

Conclusions:

• LLLT shows potential for veterinary wound management, particularly in rodents with specific wavelength parameters.
• Further research is essential to elucidate optimal LLLT protocols for rabbits, canines, and equines.
• Investigating factors like health status, treatment intervals, wavelength, and energy density is critical for validating PBM efficacy in veterinary medicine.