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Neurostimulation System Setup and Symptom Collection for Personalized Treatment of Depression

Neurostimulation System Setup and Symptom Collection for Personalized Treatment of Depression

Source: Sellers, K. K. et al. Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder. J. Vis. Exp. (2023)This video demonstrates the procedure for system setup and data recording to support patient-specific biomarker detection and neurostimulation delivery for treating major depressive...

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Extracellular depletion of fluorescently labeled glucose correlates with glucose uptake and could be used for high-throughput screening of glucose uptake in excised organs and cell cultures.

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

Detecting Establishment of Shared Blood Supply in Parabiotic Mice by Caudal Vein Glucose Injection

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Here we describe a new method of detecting successful establishment of shared blood circulation of two parabionts through a caudal vein injection of glucose, which causes minimal damage and is not fatal to the...

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Deep brain stimulation triggered by a patient-specific neural biomarker of a high-symptom state may better control symptoms of major depressive disorder compared to continuous, open-loop stimulation. This protocol provides a workflow for identifying a patient-specific neural biomarker and controlling the delivery of therapeutic stimulation based on the identified biomarker.

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes

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In this method, human primary muscle cells are cultured in vitro to obtain differentiated myotubes and glucose uptake rates are measured. We provide a detailed protocol to quantify rates in basal and insulin-stimulated states using radiolabeled [3H]...

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Related Experiment Video

Updated: Jan 20, 2026

Neurostimulation System Setup and Symptom Collection for Personalized Treatment of Depression

Neurostimulation System Setup and Symptom Collection for Personalized Treatment of Depression

Published on: June 18, 2025

How might tissue glucose influence responsive neurostimulation detection?

Kyla E Wright¹, Devon M Kollmyer², Nicole M Warner²

¹University of Washington, Department of Neurobiology, 318K Hitchcock Hall, Seattle, WA 98105, USA.

Epilepsy & Behavior Reports

|August 31, 2019

Summary

No abstract available in PubMed .

Keywords:

Biomarker Circadian Interictal Pathophysiology Prediction

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Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

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Last Updated: Jan 20, 2026

Neurostimulation System Setup and Symptom Collection for Personalized Treatment of Depression

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Published on: June 18, 2025

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Published on: April 6, 2022

Detecting Establishment of Shared Blood Supply in Parabiotic Mice by Caudal Vein Glucose Injection

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Published on: February 6, 2020