Peptide Receptor Radiotherapy: Current Approaches and Future Directions

Area of Science:

• Oncology
• Nuclear Medicine

Background:

• Neuroendocrine neoplasia (NEN) is a diverse group of tumors with complex treatment guidelines.
• The rarity of NEN limits rigorous comparative trials, complicating treatment choices.

Purpose of the Study:

• To review the current evidence and future directions for peptide receptor radionuclide therapy (PRRT) in NEN management.
• To highlight strategies for optimizing PRRT efficacy and expanding its indications.

Main Methods:

• Review of existing literature on PRRT for NEN.
• Discussion of treatment indications, optimization strategies, and future research directions.

Main Results:

• PRRT is increasingly recognized as effective for grade 1 and 2 NEN.
• Key indications include progressive disease, hormone-secretory syndromes, and tumor-related pain.

Conclusions:

• Personalized PRRT regimens and combination therapies (chemotherapy, DNA repair agents, immunotherapy) hold potential for enhanced efficacy.
• Further evolution of radiopharmaceuticals is promising for NEN treatment.