Related Experiment Video
Updated: Jan 20, 2026
Animal Models of Depression - Chronic Despair Model CDM
Published on: September 23, 2021
Repeated ketamine injections in synergy with antidepressants for treating refractory depression: A case showing
Min Wang1, Zhenzhen Xiong2, Bin Su3
1Mental Health Center and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
What Is Known And Objective:
Some patients with refractory depression who fail to respond to rapid injection of standard-dose ketamine are injected with high doses, but the safety and efficacy of this practice are unclear.
Case Description:
A 57-year-old woman with refractory depression whose symptoms did not improve after 20-seconds intravenous injection of 0.5 mg/kg ketamine went into remission following eight, 1-minute intravenous injections of 1 mg/kg ketamine delivered over a 4-week period. By 6-month follow-up, no significant adverse events had occurred and cognitive function had improved.
What Is New And Conclusion:
High-dose intravenous injections of ketamine may stably improve depressive symptoms and cognitive function in patients with refractory depression who do not respond to rapid intravenous injection of standard-dose ketamine. The high-dose treatment appears to be associated with only mild side effects.
Related Concept Videos
05:47Animal Models of Depression - Chronic Despair Model (CDM)
07:05Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
09:30Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil
05:42The Forced Swim Test as a Model of Depressive-like Behavior
04:29Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
05:35Experience is Instrumental in Tuning a Link Between Language and Cognition: Evidence from 6- to 7- Month-Old Infants' Object Categorization