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Updated: Jan 20, 2026
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Reversible turn-on fluorescent Cu(ii) sensors: rather dream than reality?
Enrico Falcone1, Angélique Sour1, Vincent Lebrun1
1Institut de Chimie, UMR 7177, CNRS-Université de Strasbourg, 4 rue Blaise Pascal, 67000, Strasbourg, France. pfaller@unistra.fr raibaut@unistra.fr.
Abstract:
Reversible turn-on fluorescent sensors of Cu(ii) are of high interest for biological studies. We re-investigate a reported sensor, showing that turn-on occurs via irreversible Cu(ii)-induced sensor oxidation only in the presence of acetonitrile. This prevents its application in biological studies and highlights the challenge of establishing a reversible Cu(ii) turn-on sensor.
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