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Updated: Jan 20, 2026
Amino acids: Structure, Classification, D- & L-Isomers
Modifications of amino acids using arenediazonium salts
Saumitra Sengupta1, Srinivasan Chandrasekaran1
1Department of Organic Chemistry, Indian Institute of Science, Bangalore, Karnataka 560012, India. jusaumitra@yahoo.co.uk scn@iisc.ac.in.
Abstract:
Aryl transfer reactions from arenediazonium salts have started to make their impact in chemical biology with initial forays in the arena of arylative modifications and bio-conjugations of amino acids, peptides and proteins. The unique multimodal reactivity of arenediazonium salts, ranging from thermal or photochemical radical chain reactions, Pd-catalyzed coupling to arylazo-coupling reactions, all under distinct but mild conditions, provides multiple options for side chain modifications of amino acids and peptides and in addition, site-selective protein conjugation and labelling, protein immobilization, azo-bridged macrocyclization, etc. under bio-ambient conditions. The purpose of this review is to highlight these recent advances and to stimulate interest towards broader applications of arenediazonium salts as aryl transfer agents in bioconjugation reactions.
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