Prevention of Postdental Procedure Bacteremia: A Network Meta-analysis.

Area of Science:

• Infectious Diseases
• Pharmacology
• Dental Medicine

Background:

• Postdental procedure bacteremia is a frequent complication.
• The comparative effectiveness of various prophylactic measures remains unclear.
• Evidence-based guidelines for preventing bacteremia are needed.

Purpose of the Study:

• To compare the efficacy of different prophylactic interventions for preventing postdental procedure bacteremia.
• To identify optimal strategies for reducing bacteremia incidence in patients undergoing dental procedures.

Main Methods:

• A comprehensive literature search was conducted across multiple databases (ClinicalKey, Cochrane CENTRAL, Embase, ProQuest, PubMed, ScienceDirect, Web of Science, ClinicalTrials.gov).
• Randomized controlled trials evaluating prophylactic interventions for postdental procedure bacteremia were included.
• A network meta-analysis was performed to compare the incidence of bacteremia across interventions.

Main Results:

• Twenty-four trials with 2,147 participants were analyzed.
• Intravenous amoxicillin/clavulanate showed the lowest incidence of bacteremia (OR = 0.03).
• Oral amoxicillin demonstrated the lowest incidence among oral/topical interventions (OR = 0.10).

Conclusions:

• Intravenous amoxicillin/clavulanate and oral amoxicillin appear to be the most effective prophylactic interventions for preventing postdental procedure bacteremia.
• No serious adverse events were reported in the included trials.
• These findings provide valuable insights for clinical practice in managing postdental procedure bacteremia.