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Related Experiment Videos

Decrease of bleeding time by a peptide fraction from bovine factor VIII in laboratory animals.

G B Gervasi1, C Bartoli, G Carpita

  • 1Baldacci Research Laboratories, Pisa, Italy.

Arzneimittel-Forschung
|September 1, 1988
PubMed
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A novel peptide fraction from bovine Factor VIII, named Vueffe, effectively reduces bleeding time in various animal models. This hemostatic agent shows promise, particularly in pathological conditions, without impacting platelets or coagulation.

Area of Science:

  • Biochemistry
  • Hematology
  • Pharmacology

Background:

  • Bovine Factor VIII is crucial for blood coagulation.
  • Enzymatic hydrolysis can yield bioactive peptide fractions.
  • Low molecular weight peptides may possess therapeutic properties.

Purpose of the Study:

  • To investigate the hemostatic action of a peptide fraction derived from bovine Factor VIII (Vueffe).
  • To evaluate the efficacy of Vueffe across different animal species and experimental conditions.
  • To determine the mechanism of action, specifically its effect on platelets and blood coagulation.

Main Methods:

  • Preparation of a low molecular weight peptide fraction from bovine Factor VIII via enzymatic hydrolysis.
  • Administration of the peptide fraction to mice, rats, and rabbits via different routes.

Related Experiment Videos

  • Assessment of hemostatic activity by measuring bleeding time under normal and experimentally prolonged conditions.

    • Main Results:

    • The peptide fraction (Vueffe) significantly reduced bleeding time in mice, rats, and rabbits.
    • Efficacy was observed in both normal and pathologically prolonged bleeding time models.
    • The compound demonstrated activity at very low doses across all tested species.
    • Vueffe did not interfere with platelet function or the blood coagulation cascade.

    Conclusions:

    • Vueffe, a peptide fraction of bovine Factor VIII, possesses significant hemostatic properties.
    • Its efficacy in pathological bleeding situations suggests therapeutic potential.
    • The compound acts through a novel mechanism independent of platelets and coagulation factors.