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Anaphylactic reactions to cinoxacin
B H Stricker1, G Slagboom, R Demaeseneer
1Netherlands Centre for Monitoring of Adverse Reactions to Drugs, Rijswijk.
BMJ (Clinical Research Ed.)
|December 3, 1988
Summary
Anaphylactic reactions, including shock, can occur after cinoxacin treatment. Prompt emergency care led to recovery, but caution is advised when prescribing this quinolone derivative.
Area of Science:
- Pharmacovigilance
- Clinical Toxicology
Background:
- Cinoxacin, a quinolone derivative, is used for urinary tract infections.
- Adverse drug reactions are monitored globally to ensure patient safety.
Observation:
- Three cases of anaphylactic shock and 17 anaphylactic-type reactions to cinoxacin were reported between 1981 and mid-1988.
- Reactions often occurred shortly after initiating a subsequent course of cinoxacin treatment.
Findings:
- Cinoxacin can induce severe anaphylactic reactions, including anaphylactic shock.
- Cross-reactivity may exist between quinolone antibiotics, as suggested by a case involving nalidixic acid and cinoxacin.
Implications:
- Healthcare providers should exercise caution when prescribing cinoxacin and other quinolones due to the risk of potentially fatal anaphylactic reactions.
- Prompt medical intervention with plasma expanders, adrenaline, and corticosteroids is effective in managing these adverse events.
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