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Related Experiment Videos

Anaphylactic reactions to cinoxacin.

B H Stricker1, G Slagboom, R Demaeseneer

  • 1Netherlands Centre for Monitoring of Adverse Reactions to Drugs, Rijswijk.

BMJ (Clinical Research Ed.)
|December 3, 1988
PubMed
Summary
This summary is machine-generated.

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Anaphylactic reactions, including shock, can occur after cinoxacin treatment. Prompt emergency care led to recovery, but caution is advised when prescribing this quinolone derivative.

Area of Science:

  • Pharmacovigilance
  • Clinical Toxicology

Background:

  • Cinoxacin, a quinolone derivative, is used for urinary tract infections.
  • Adverse drug reactions are monitored globally to ensure patient safety.

Observation:

  • Three cases of anaphylactic shock and 17 anaphylactic-type reactions to cinoxacin were reported between 1981 and mid-1988.
  • Reactions often occurred shortly after initiating a subsequent course of cinoxacin treatment.

Findings:

  • Cinoxacin can induce severe anaphylactic reactions, including anaphylactic shock.
  • Cross-reactivity may exist between quinolone antibiotics, as suggested by a case involving nalidixic acid and cinoxacin.

Implications:

  • Healthcare providers should exercise caution when prescribing cinoxacin and other quinolones due to the risk of potentially fatal anaphylactic reactions.

Related Experiment Videos

  • Prompt medical intervention with plasma expanders, adrenaline, and corticosteroids is effective in managing these adverse events.