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Related Concept Videos

Generation of a Murine Model with a Central Nervous System Infection02:21

Generation of a Murine Model with a Central Nervous System Infection

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This video demonstrates the generation of a mouse model with a CNS infection. A suckling pup is injected with the virus both intracranially and intraperitoneally. The virus spreads, infecting the CNS causing neuronal cell death and inflammation. The pup is assessed for symptoms of infection as the disease...
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We outline methods for the efficient and quick isolation/culture of viable microglia from the neonatal cerebral cortex and adult spinal cord. The dissection and plating of cortical microglia can be accomplished within 90 minutes, with the subsequent microglial harvest taking place ~ 10 days following the initial...
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Optical clearing techniques are revolutionizing the way tissues are visualized. In this report we describe modifications of the original Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging-compatible Tissue-hYdrogel (CLARITY) protocol that yields more consistent and less expensive...
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Source: Chen, Y., et al. Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System. J. Vis. Exp. (2019)This video demonstrates the delivery of a test compound into the cerebrospinal fluid (CSF) through a catheter implanted in the lumbar spinal column of a rat model. The compound circulates along the CSF to the brain and spinal cord, enters neurons, and offers therapeutic...
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Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE20:51

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In this video we demonstrate how to isolate mononuclear cells from the central nervous system of rats with experimental autoimmune encephalomyelitis.
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We describe a method to target drugs to the central nervous system by either implanting a catheter or performing a bolus injection into the right lateral ventricle in mice. We focus specifically on the delivery of antisense oligonucleotides. This technique is readily adaptable to other drugs and to...
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Related Experiment Video

Updated: Jan 20, 2026

Culturing Microglia from the Neonatal and Adult Central Nervous System
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Primary Central Nervous System Angiosarcoma.

Mengqi Gao1, Pengfei Li1, Chunyu Tan1

  • 1Department of Neurosurgery, First Hospital of China Medical University, Shenyang, China.

World Neurosurgery
|August 31, 2019
PubMed
Summary
This summary is machine-generated.

Primary brain angiosarcoma is a rare vascular tumor. This case highlights diagnostic challenges and poor prognosis, emphasizing the need for awareness among neurosurgeons and radiologists.

Area of Science:

  • Neuro-oncology
  • Vascular Tumors
  • Pathology

Background:

  • Primary brain angiosarcoma is an exceedingly rare malignant neoplasm.
Keywords:
AngiosarcomaPrimary central nervous system tumorSurgery

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  • Originates from vascular endothelial cells within the brain or meninges.
  • Limited understanding of its clinical presentation, characteristics, and prognosis.