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Updated: Jan 20, 2026
Embedding Drosophila Brain in a Matrix for Time-Lapse Imaging of the Circadian Clock Neurons
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Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis
Cátia F Gonçalves1, Qing-Jun Meng2
1C Gonçalves, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Wellcome Trust Centre for Cell Matrix Research, Manchester, United Kingdom of Great Britain and Northern Ireland.
Abstract:
The circadian system in mammals is responsible for the temporal coordination of multiple physiological and behavioural processes that are necessary for homeostasis. In the skeleton, it has long been known that metabolic functions of chondrocytes, osteoblasts and osteoclasts exhibit intrinsic circadian rhythms. In addition, results from animal models reveal a close connection between the disruption of circadian rhythms and skeletal disorders such as rheumatoid arthritis, osteoarthritis and osteoporosis. In this review, we summarise the latest insights into the genetic and biochemical mechanisms linking cartilage and bone physiology to the circadian clock system. We also discuss how this knowledge can be utilised to improve human health.
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