Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment09:56

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment

9.6K
This protocol describes optimization procedures in a virus-based dual fluorescence-labeled tumor xenograft model using larval zebrafish as hosts. This heterogeneous xenograft model mimics the tissue composition of pancreatic cancer microenvironment in vivo and serves as a more precise tool for assessing drug responses in personalized zPDX (zebrafish patient-derived xenograft)...
9.6K
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

2.7K
This protocol describes the orthotopic implantation of patient-derived cancer cells in the cecum wall of immunodeficient mice. The model recapitulates advanced colorectal cancer metastatic disease and allows for the evaluation of new therapeutic drugs in a clinically relevant scenario of lung and liver...
2.7K
Establishment of Zebrafish Patient-Derived Xenografts from Pancreatic Cancer for Chemosensitivity Testing06:59

Establishment of Zebrafish Patient-Derived Xenografts from Pancreatic Cancer for Chemosensitivity Testing

1.7K
Preclinical models aim to advance the knowledge of cancer biology and predict treatment efficacy. This paper describes the generation of zebrafish-based patient-derived xenografts (zPDXs) with tumor tissue fragments. The zPDXs were treated with chemotherapy, the therapeutic effect of which was assessed in terms of cell apoptosis of the transplanted tissue.
1.7K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

650
The study found that male gender, poor tumor grade, and advanced Tumor Node Metastasis stage were associated with poorer cancer-specific survival (CSS) in multiple primary colorectal cancer (MPCC) patients after surgery. We developed a nomogram to predict the CSS of MPCC patients and contribute to clinical treatment...
650
An Orthotopic Resectional Mouse Model of Pancreatic Cancer07:17

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

12.3K
In the clinical context, patients with localized pancreatic cancer will undergo pancreatectomy followed by adjuvant treatment. This protocol reported here aims to establish a safe and effective method of modelling this clinical scenario in nude mice, through orthotopic implantation of pancreatic cancer followed by distal pancreatectomy and...
12.3K
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

20.1K
Pancreatic cancer stem cells (CSCs) can be expanded in vitro using the anchorage-independent sphere culture technique, which represents a powerful tool to study CSC biology and can serve as the first step to develop novel CSC-targeting therapies. Here the methodology for expanding, analyzing and targeting of pancreatic CSCs is...
20.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nomogram to predict survival of patients with advanced and metastatic pancreatic Cancer.

BMC cancer·2021
Same author

Identification of DNA methylation-driven genes and construction of a nomogram to predict overall survival in pancreatic cancer.

BMC genomics·2021
Same author

Timing of chemotherapy-induced neutropenia is a prognostic factor in patients with advanced gastric cancer undergoing first-line chemotherapy with oxaliplatin and capecitabine: a retrospective study.

Cancer medicine·2018
Same author

Determining the requirements for cooperative DNA binding by Swi5p and Pho2p (Grf10p/Bas2p) at the HO promoter.

The Journal of biological chemistry·1995
Same author

The reliability of cigarette consumption reports by spousal proxies.

American journal of public health·1995
Same author

Inhibition of trypsin with active-site-directed enzyme-activated nitrosoamide substrates.

Biochemistry·1995
Same journal

Plexin A2 regulated the metastasis in breast cancer through MCM7.

BMC cancer·2026
Same journal

Spatial profiling of tissue-resident memory T cells reveals stromal IL-15 niches and a paradoxical CD103⁺ phenotype predicting survival in oral squamous cell carcinoma.

BMC cancer·2026
Same journal

Epidemiological trends of non-small cell lung cancer and systemic treatment rates as part of initial therapeutic strategy from 2016 to 2020 in Greece: results of the epidemiological part of INFINITY study.

BMC cancer·2026
Same journal

Multi-level stakeholder perspectives on barriers and facilitators to engaging older adult cancer survivors in mental health treatment.

BMC cancer·2026
Same journal

Preliminary study on the mechanism of OPN up-regulating PD-L1 to induce CD8 + T cell exhaustion in synovial sarcoma.

BMC cancer·2026
Same journal

Benefits and challenges of adding BKM120 to a BI-3406 plus trametinib combination therapy.

BMC cancer·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment
09:56

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment

Published on: April 30, 2019

9.6K

CA19-9 decrease and survival according to platelet level in patients with advanced pancreatic cancer.

Y Chen1,2, Y R Wang1, G C Deng1

  • 1Department of Medical Oncology, Chinese People's Liberation Army (PLA) General Hospital and Chinese PLA Medical School, Beijing, 100853, China.

BMC Cancer
|September 1, 2019
PubMed
Summary
This summary is machine-generated.

A decrease in cancer antigen 19-9 (CA19-9) levels during treatment is linked to better survival in pancreatic cancer patients, especially those with low platelet counts. This suggests a potential interaction between platelets and tumor cells.

Keywords:
CA19–9ChemotherapyPancreatic cancerPlateletPrognosis

More Related Videos

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

2.7K
Establishment of Zebrafish Patient-Derived Xenografts from Pancreatic Cancer for Chemosensitivity Testing
06:59

Establishment of Zebrafish Patient-Derived Xenografts from Pancreatic Cancer for Chemosensitivity Testing

Published on: May 12, 2023

1.7K

Related Experiment Videos

Last Updated: Jan 20, 2026

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment
09:56

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment

Published on: April 30, 2019

9.6K
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

2.7K
Establishment of Zebrafish Patient-Derived Xenografts from Pancreatic Cancer for Chemosensitivity Testing
06:59

Establishment of Zebrafish Patient-Derived Xenografts from Pancreatic Cancer for Chemosensitivity Testing

Published on: May 12, 2023

1.7K

Area of Science:

  • Oncology
  • Biomarkers
  • Cancer Research

Background:

  • The prognostic value of CA19-9 decrease in pancreatic cancer survival is established.
  • Limited evidence exists on the correlation between high platelet levels and poor survival in pancreatic cancer.
  • The interplay between CA19-9 dynamics and platelet levels in metastatic pancreatic cancer survival remains unclear.

Purpose of the Study:

  • To investigate the association between CA19-9 decrease and survival in advanced pancreatic cancer.
  • To explore whether this association is modified by baseline platelet levels.
  • To elucidate the role of platelet levels in the prognostic significance of CA19-9 response.

Main Methods:

  • Serum CA19-9 and platelet levels were measured in 200 advanced pancreatic cancer patients at baseline and after chemotherapy.
  • Cox proportional hazards models were employed to assess mortality hazard ratios (HRs) for CA19-9 decrease.
  • Analyses were adjusted for confounders including age, KPS, BMI, comorbidities, and treatment regimens.

Main Results:

  • The association of CA19-9 decrease with superior overall survival was significantly stronger in patients with low platelet levels (Pinteraction < 0.001).
  • Multivariable-adjusted HRs per unit decrease of CA19-9 were 0.45 for low, 0.74 for intermediate, and 0.94 for high platelet levels.
  • A similar interaction was observed between CA19-9 decrease and progression-free survival across different platelet strata (Pinteraction = 0.034).

Conclusions:

  • CA19-9 decrease is associated with improved pancreatic cancer survival, particularly in patients with low platelet counts.
  • These findings suggest a potential role for platelet-tumor cell interactions in pancreatic cancer progression.
  • The study highlights the importance of considering platelet levels when interpreting CA19-9 response as a prognostic marker.