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[Bone marrow plasma cell reaction in alcoholic patients]
Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
|January 1, 1979
Summary
Alcoholism impacts bone marrow by increasing plasma cells, indicating preserved B cell function and heightened protein synthesis. This suggests an overactive immune response in alcoholic conditions.
Area of Science:
- Immunology
- Hematology
- Pathology
Background:
- Alcoholism and alcoholic psychoses are associated with various systemic effects.
- Bone marrow plays a crucial role in immune cell production and function.
Purpose of the Study:
- To investigate the plasmacytic reactions in the bone marrow of individuals with alcoholism and alcoholic psychoses.
- To understand the implications of these reactions on immune system function.
Main Methods:
- Histological examination of bone marrow samples.
- Analysis of plasma cell morphology and quantity.
- Assessment of cellular reactions like basophilia and clasmatosis.
Main Results:
- Demonstrated a significant increase in the number of plasma cells in the bone marrow.
- Observed a prevalence of mature plasma cells exhibiting marked basophilia.
- Identified a reaction of clasmatosis in the plasma cells.
Conclusions:
- The findings suggest a preserved function of the B cell system, the source of plasma cells, in alcoholism.
- Indicates an elevated level of protein synthesis, including antibodies.
- Suggests a dominance of the productive phase of immunogenesis over the adaptive phase in alcoholic conditions.