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Related Concept Videos

Bacterial Transformation01:33

Bacterial Transformation

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In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
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Agrobacterium tumefaciens and Agrobacterium rhizogenes-Mediated Transformation of Potato and the Promoter Activity of a Suberin Gene by GUS Staining08:31

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Here, we present two protocols to transform potato plants. The Agrobacterium tumefaciens transformation leads to a complete transgenic plant while the Agrobacterium rhizogenes produces transgenic hairy roots in a wild type shoot that can be self-propagated. We then detect promoter activity by GUS staining in the transformed...
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The Eukaryotic Promoter Region02:40

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The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
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Plant Promoter Analysis: Identification and Characterization of Root Nodule Specific Promoter in the Common Bean10:58

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Promoter expression analyses are crucial to improving the understanding of gene regulation and the spatiotemporal expression of target genes. Herein we present a protocol to identify, isolate, and clone a plant promoter. Further, we describe the characterization of the nodule-specific promoter in the common bean hairy...
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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

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DNA regulatory elements, such as enhancers, control gene expression by physically contacting target gene promoters, often through long-range chromosomal interactions spanning large genomic distances. Promoter Capture Hi-C (PCHi-C) identifies significant interactions between promoters and distal regions, enabling the assignment of potential regulatory sequences to their target...
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The goal of the protocol is to provide an industrialized fish fermentation technique based on inoculation of Saccharomyces...
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Patient-, Provider-, and Area-Level Factors Associated with Hepatocellular Carcinoma Surveillance in Patients with Cirrhosis in North Carolina.

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Related Experiment Video

Updated: Jan 20, 2026

Agrobacterium tumefaciens and Agrobacterium rhizogenes-Mediated Transformation of Potato and the Promoter Activity of a Suberin Gene by GUS Staining
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Agrobacterium tumefaciens and Agrobacterium rhizogenes-Mediated Transformation of Potato and the Promoter Activity of a Suberin Gene by GUS Staining

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Promoting Quality in Medicaid Transformation.

J Thomas Newton1, Troy Hildreth2

  • 1medical director, WellCare of North Carolina, Raleigh, North Carolina John.newton@WellCare.com.

North Carolina Medical Journal
|September 1, 2019
PubMed
Summary

North Carolina is transitioning to Medicaid managed care, focusing on whole-person treatment. WellCare of North Carolina will implement innovative strategies to enhance care quality by adapting successful programs from other states.

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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Agrobacterium tumefaciens and Agrobacterium rhizogenes-Mediated Transformation of Potato and the Promoter Activity of a Suberin Gene by GUS Staining
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Plant Promoter Analysis: Identification and Characterization of Root Nodule Specific Promoter in the Common Bean
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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Area of Science:

  • Health Services Research
  • Public Health Policy
  • Healthcare Management

Background:

  • North Carolina is undergoing a significant transition to a Medicaid managed care model.
  • The current system emphasizes whole-person treatment, providing a foundation for future improvements.
  • Managed care offers opportunities to integrate and enhance existing service quality.

Purpose of the Study:

  • To outline WellCare of North Carolina's strategy for the upcoming Medicaid managed care implementation.
  • To leverage innovative approaches for improving the quality of healthcare services.
  • To adapt successful managed care models from other states to the North Carolina context.

Main Methods:

  • Review of successful Medicaid managed care programs in other states.
  • Analysis of North Carolina's specific healthcare needs and existing service quality.
  • Development of tailored strategies integrating best practices for whole-person care.

Main Results:

  • Anticipated improvement in the quality of care through integrated services.
  • Successful adaptation of proven managed care strategies to a new state context.
  • Enhanced focus on whole-person treatment within the Medicaid program.

Conclusions:

  • The transition to Medicaid managed care in North Carolina presents a strategic opportunity for service enhancement.
  • WellCare of North Carolina's planned approach is designed to build upon existing strengths and improve overall care quality.
  • Innovative, state-specific strategies are crucial for maximizing the benefits of managed care.